Total Pancreatectomy: Removal of the entire pancreas is utilized on occasion to treat chronic pancreatitis when other treatments are unsuccessful. This operation has no additional complication rate compared to the Whipple procedure. Removal of all the insulin-producing cells of the entire pancreas may cause a form of diabetes that is difficult to manage. Some hospitals and surgeons offer total pancreatectomy combined with transplantation of the patient's own insulin-producing cells, (Auto Islet Transplantation) in order to keep the patients from becoming diabetic. (TP/ICT)
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Auto Islet Transplantation: Transplantation of the pancreatic cells that produce insulin (islet cells) has been studied for many years, and usually involved transplanting healthy islet cells from a cadaver donor to a diabetic patient. This requires medicines to fight rejection of cells transplanted between different individuals.
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In patients with chronic pancreatitis, it is possible to remove the entire pancreas and to harvest islet cells from the pancreas.Patients can have their own insulin-producing cells transplanted and do not need to worry about rejecting these cells. This has been done with success since 1977, and is a promising new area in the treatment of chronic pancreatitis. In particular, it is useful in patients who have a pancreas that has healthy insulin-producing cells. This could include patients who have familial pancreatitis, pancreas divisum or sphincter of Oddi dysfunction.
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In patients with chronic pancreatitis, it is possible to remove the entire pancreas and to harvest islet cells from the pancreas.Patients can have their own insulin-producing cells transplanted and do not need to worry about rejecting these cells. This has been done with success since 1977, and is a promising new area in the treatment of chronic pancreatitis. In particular, it is useful in patients who have a pancreas that has healthy insulin-producing cells. This could include patients who have familial pancreatitis, pancreas divisum or sphincter of Oddi dysfunction.
..Once the pancreas is removed, it is taken to the lab where the islets are harvested from the patient's own pancreas.
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The islets are then placed into the liver through the Portal Vein.
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To view information on another disease, click on SOD and Pancreatitis Library.!
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6 comments:
I would love to hear back from someone who has undergone a total pancreatectomy and has had the Auto Islet Transplant done! My cousin (who I am close with and her DPOA), has been in and out of the hospital for many years with complications from Lupus. The past year and a half she has had chronic pancreatitis, and has been on medications, and had several surgeries...She gets sick again with it, just as soon as she gets better! The doctors at Northwestern spoke to us about a total pancreatectomy and AIT, and said that it may be the next step if her last surgery did not help. She was home only a week later, when she began another attack. So, this is looking to be the best solution to me for her, but I would love to hear feedback from someone who has been through it! If you can help me/her, I would greatly appreciate it! Thank you!
Sincerely,
Jacqueline
jacqueline923@hotmail.com
My family has Familial Hereditary Pancreatitis...resulting in both my son and I ending up chronic severe pancreatitis. With every attack our pancreases, and everyone's who suffers from pancreatitis, became more damaged and attacks increased. In 2005 my son had an auto islet transplant-total pancreatectomy and in 2006 I had one. It gave us our lives back!!! We had suffered with the pancreatitis attacks for years so they were unable to harvest the needed islets so we are both diabetic...but this is a "cake walk" compared to pancreatitis. We also have to injest digestive enzymes every time we eat and this is a bit of a hassel. But again, nothing compared to the constant use of pain killers and hospitalizations and extreme pain. I was disabled for 13 years and now am back to work and able to live again. I know that a pancreatectomy is a major surgery but it was definitly worth if for us.
James
marthaler1031@gmail.com
My family has Familial Hereditary Pancreatitis...resulting in both my son and I ending up chronic severe pancreatitis. With every attack our pancreases, and everyone's who suffers from pancreatitis, became more damaged and attacks increased. In 2005 my son had an auto islet transplant-total pancreatectomy and in 2006 I had one. It gave us our lives back!!! We had suffered with the pancreatitis attacks for years so they were unable to harvest the needed islets so we are both diabetic...but this is a "cake walk" compared to pancreatitis. We also have to injest digestive enzymes every time we eat and this is a bit of a hassel. But again, nothing compared to the constant use of pain killers and hospitalizations and extreme pain. I was disabled for 13 years and now am back to work and able to live again. I know that a pancreatectomy is a major surgery but it was definitly worth if for us.
James
marthaler1031@gmail.com
I had my surgery five years ago. I would tell Docs if not enough islet cells to be insulin independent, DON'T do that part of the surgery. Save the liver. I got 150000 cells and a fatty liver with the most brittle form of diabetes there is. I feed through a process called TPN because of malabsorption. Be careful! I went to Minnesota to Dr David Sutherland. Awesome care there! Don't forget about caringbridge.com. Super helpful in informing and connecting loved ones. Good luck!
I had the surgery nearly 11 years ago in Minnesota. I now live a normal life. So thankful for the surgery.
I had the surgery nearly 11 years ago in Minnesota. I now live a normal life. So thankful for the surgery.
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